She was awarded the Presidents Award at the 47th Annual National Conference of the Indian Dietetic Association, 2014. The extract of the seeds of milk thistle contains a number of substances, collectively called silymarin. Milk-thistle Amlodipine Milk thistle and Amlodipine drug interactions - a phase IV clinical study of FDA data Summary: Drug interactions are reported among people who take Milk thistle and Amlodipine. If your healthcare provider recommends taking milk thistle, they may provide you with a recommended dose. Keep all medications and herbal products away from children and pets. 7 herbs and supplements for type 2 diabetes, Do liver cleanses work? Verywell Health's content is for informational and educational purposes only. Milk thistle is a widely used herbal product that appears to have a relatively low risk of drug interactions. This is not a complete list of side effects and others may occur. Vegetable Oil: Nutrition Fac Olive Oil Vs. A 2015 study found that it helped to improve inflammatory skin conditions when applied to the skin of mice. Does Milk Thistle Capsule interact with other drugs you are taking? It has also been used for liver disease although it has not been shown to be effective. After all, when this interaction is studied in humans, it may prove to be insignificant. Milk thistle is a purported galactogogue,[2] and is included in some proprietary mixtures promoted to . Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. Yes, you can take milk thistle long term. Possibly. 2008;47(2):605-12. doi:10.1002/hep.22044. Consult your doctor before breast-feeding. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Click here for additional information. The terms "milk thistle" and "silymarin" are often used interchangeably. Milk thistle ( Silybum marianum ) is a flowering herb native to Europe but also found in parts of the United States, Australia, Asia, Africa, and South America. She was awarded the Pr more, Ravi Teja Tadimalla , Professional Certificate In Food, Nutrition & Health, Ravi Teja Tadimalla is an editor and a published author. NCCIH has provided this material for your information. It also seems to have antioxidant and anti-inflammatory effects. Milk thistle is an annual or biennial herb native to the Mediterranean region, which has been used for centuries as a food and as a medicinal herb for treatment of liver conditions. Does milk thistle interact with my other drugs? Milk thistle is native to the Mediterranean region. We explore the potential health benefits of milk thistle below. Moderately clinically significant. Duplication is encouraged. Call your doctor for medical advice about side effects. Consult your doctor before using this product. Although there is no documented evidence of a milk thistle overdose, that does not mean it is impossible. She has 14 years of experience in Clinical Nutrition as well as teaching Nutrition and Dietetics to undergraduate and postgraduate students. Liver cleanses promise to rid the body of toxins and impurities, but are controversial because there is little science to support their use. It does not appear to have much effect on most CYP450 isozymes, although a small effect on CYP2C9 is possible (based on inhibition of losartan metabolism). Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. The following two tabs change content below. The study looked specifically at bone loss caused by a deficiency in estrogen among rats that had their ovaries removed. The most common use of milk thistle is for liver problems. This document does not contain all possible interactions. Enter your medication into the WebMD interaction checker, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Fitness vs. Sebagai suplemen makanan, minum 1-2 kapsul setiap hari sebaiknya dengan makanan atau seperti . Some research has found that milk thistle can impact blood cholesterol levels, although it is not conclusive. When looking at Milk Thistle itself (prior to any extraction), the fruits or thistles contain: Silymarin at 1.5-3% of dry weight (to be elucidated later) [2] Silyhermin and both Neosilyhermin A and B [2]; Protein and Mucilage (taking up 25-30% of the herb by dry weight) [2] Quercetin and the dihydro varient known as Taxifolin [2]; Kaempferol, Dihydrokaempferol, and the 7-glucoside and 3 . However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. Horn and Hansten are both professors of pharmacy at the University of Washington School of Pharmacy. Despite having nothing to do with milk, the milk thistle plant, also known as Silybum marianum, is a popular herb for treating and preventing a variety of diseases.. Talk to your pharmacist for more details. Weight Loss for Health and Longevity, Science Reveals How Red Meat Harms the Heart, Flavored Vapes Still in Stores Despite Federal Ban, New COVID Antiviral Pills: What You Need to Know, Dr. Whyte's Book: Take Control of Your Cancer Risk, WebMD Loses Cherished Leader Kristy Hammam, Health News and Information, Delivered to Your Inbox. Historically, people have used milk thistle for liver disorders and gallbladder problems. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. The survey revealed anecdotal evidence of the improved quality of life among those who took milk thistle, despite having no measurable improvements in hepatitis symptoms like liver inflammation. Copyright 2011 - 2023 IncNut Stylecraze Private Limited. Studies of milk thistle coadministered with various drugs in humans suggest it is unlikely to affect the most common cytochrome, the P450 (CYP450) isozyme. Store milk thistle supplements in a cool, dry place. Mothers who used milk thistle to boost their milk production reported unwanted weight gain along with irritability and nausea (16). Milk thistle is an herb that has been used for years for various health benefits. JAMA. Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials. Learn more about the other negative effects of this herb and what research says about them. Keep in mind, though, that it is unknown if milk thistle tea provides the same suggested benefits as milk thistle supplements. Biomed Res Int. As with any natural remedy, people should discuss using milk thistle with a doctor before taking it. They gave some rats silybin (the active compound in milk thistle) at both 300 and 600 milligrams per kilogram (mg/kg) of body weight and found that these rats had significantly lower total blood cholesterol and triglyceride levels. Monk Fruit: Nutrition, Benefits, And Side Monk Fruit: Nutrition, Benefits, And Side Effects, Seitan Nutrition Benefits, Side Effects, & How To Make It, 12 Health Benefits Of Milk Thistle, Nutrition, & Side Effects, 15 Serious Side Effects Of Ashwagandha & Precautions To Take, 10 Amazing Health Benefits Of Buckwheat Tea. Follow all directions on the product package. Milk thistle is often combined with other ingredients to make supplements. Milk thistle is thought to be safe for most people, but precautions should be taken as side effects are possible. Loguercio C, Festi D. Silybin and the liver: from basic research to clinical practice. In:Drugs and Lactation Database (LactMed). Dosage: How Much Milk Thistle Should I Take? However, many of these potential benefits are not backed by science. Olive Oil Vs. Milk thistle (Silybum marianum) is a herb loaded with antioxidants and is known for its anti-inflammatory properties. In a 2016 study, researchers fed rats a high-cholesterol diet. Some people also call it Mary thistle and holy thistle. A double-blind controlled study. Milk thistle has not been implicated in causing liver injury and is still used widely as a liver tonic in patients with acute and chronic liver diseases. Rambaldi, A.; Jacobs, B.; Iaquinto G, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C liver diseases--a systematic Cochrane hepato-biliary group review with meta-analyses of randomized clinical trials. This article explores potential milk thistle benefits and examines whether there is any scientific evidence to support its use. On extremely rare occasions, milk thistle has caused severe allergic reactions as well as anaphylaxis, a potentially life-threatening allergic reaction. The review went on to say that silymarin may be linked to lower rates of mortality in patients with cirrhosis and liver disease. Am J Gastroenterol. Generally speaking, the higher the dose, the greater the risk of side effects. The common name, milk thistle, is derived from the "milky white" veins on the leaves, which, when broken open, yield a milky sap. Read our. No supplement is intended to treat, cure, or prevent disease. Rev Diabet Stud. Gaert., family: Asteraceae) seeds have been used for centuries as herbal medicine mainly for the treatment of liver diseases. 2014;11(2):167-74. doi:10.1900/RDS.2014.11.167. Fried, M.; Navarro, V.; Afdhal, N. et al. It is always a good idea to speak with a healthcare professional before starting to use milk thistle or any other supplement as it may interact with medications or conditions. StatPearls Publishing; 2022. 3. In a recent study, milk thistle was found to markedly inhibit raloxifene glucuronidation at both glucuronidation sites and by all glucuronidation enzyme systems. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Voroneanu L, Nistor I, Dumea R, Apetrii M, Covic A. Silymarin in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials. Enter other medications to view a detailed report. Milk thistle may interact with certain medications. Regardless, interactions are still possible. Dietary supplements are not regulated like drugs in the United States, meaning the Food and Drug Administration (FDA) does not approve them for safety and effectiveness before products are marketed. gallbladder disorders. Phytother Res. In some studies, silibinin, an active component of milk thistle, has been shown to have estrogen-like effects. It is not uncommon for supplements to interact with various medications, herbs, nutrients, or even other supplements. Adv Ther. Call your doctor for medical advice about side effects. We encourage you to discuss any decisions about treatment or care with your health care provider. What Happens If I Take Too Much Milk Thistle? According to researchers, these findings suggest that silymarin may improve diabetes symptoms like oxidative stress and inflammation. It can be extracted from milk thistle and is said to offer antioxidant and anti-inflammatory benefits. No related drugs found for this medication. milk thistle. Milk thistle may help strengthen a persons immune response. Save the high-quality PDF version on your device now. What Are the Side Effects of Milk Thistle? hepatitis. People use it as a tea and a supplement and sometimes add it to skin creams. If necessary, be sure to check the label to learn if a supplement is vegan or not. Common side effects of milk thistle reported in studies include: Typically, side effects will subside once you stop using milk thistle. However, there is a lack of . Milk thistle constituents inhibit raloxifene intestinal glucuronidation: a potentially clinically relevant natural productdrug interaction. Studies show that silymarin may help ease inflammation and promote cell repair. Milk thistle: early seeds of potential, The Lancet Oncology, US National Library of Medicine, National Institutes of Health. Ebrahimpour, K.; Gargari, B.; Mobasseri, M. et al. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. 2023 Dotdash Media, Inc. All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Hence, limit its usage if you experience any adverse reactions. However, researchers theorize that it does. You can buy milk thistle online in the supplement form. ODS seeks to strengthen knowledge and understanding of dietary supplements by evaluating scientific information, supporting research, sharing research results, and educating the public. Milk thistle is a herbal product widely used in the United States and around the world. For guidance from NCCIH on using PubMed, see How To Find Information About Complementary Health Approaches on PubMed. He has been in the digital media field for over eight years. Soleimani V, Delghandi PS, Moallem SA, Karimi G. Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review. Common Names:milk thistle, Mary thistle, holy thistle, Latin Names:Silybum marianum, synonym Carduus marianus. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. (2021). Cathy Wong is a nutritionist and wellness expert. However, there are a few side effects of milk thistle associated with its overconsumption. Is there also a role for herbs and supplements? 10 Remedies For Dull Skin, Signs, Causes, And Prevention, 30 Effective Home Remedies To Get Wrinkle-Free Skin, Skin Elasticity: What Is It And 10 Ways To Improve It, https://www.ncbi.nlm.nih.gov/books/NBK11896/, https://nccih.nih.gov/health/milkthistle/ataglance.htm, https://www.ncbi.nlm.nih.gov/books/NBK541075/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538855/, https://www.frontiersin.org/articles/10.3389/fonc.2019.01356/full, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164972/, https://journals.sagepub.com/doi/pdf/10.1177/1534735407301942, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116427/, https://www.ncbi.nlm.nih.gov/pubmed/25396404, https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/silybum-marianum, https://www.karger.com/Article/Fulltext/334488, https://www.ncbi.nlm.nih.gov/books/NBK65780/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586829/, https://pubmed.ncbi.nlm.nih.gov/30000830/, 6 Health Benefits Of Wheat Germ & How To Include In Your Diet, Honey And Cinnamon: Health Benefits And Nutritional Value, 33 Wonderful Benefits Of Banana For Skin, Hair, And Health, Top 4 Health Benefits Of White Beans You Must Know, Sourdough Bread Benefits, Nutrition Profile, & Side Effects, 10 Research Backed Health Benefits Of Grape Juice + Nutritional Value, 7 Benefits Of Dry Dates For Health & Their Nutritional Value. High cholesterol can lead to problems with heart health and increase a persons chance of stroke. 2020;37(4):1279-1301. doi:10.1007/s12325-020-01251-y. Investigating the Potential for Toxicity From Long-Term Use of the Herbal Products, Goldenseal and Milk Thistle, Toxicologic Pathology, US National Library of Medicine, National Institutes of Health. The effects of milk thistle (Silybum marianum) on human cytochrome P450 activity. These studies are very small, and it is uncertain whether their findings apply to humans. He has been in the digital media field for over eight years. Little is known about whether its safe to use milk thistle during pregnancy or while breastfeeding. But the herb is also believed to be beneficial for other health issues. Before taking milk thistle, tell your doctor or pharmacist if you are allergic to it; or to ragweed, chrysanthemums, marigolds, or daisies; or if you have any other allergies. Han YU, Guo D, Chen Y, et al. Herbal remedies are usually the talk of the town. Milk thistle side effects (more detail) However, there are a few side effects of milk thistle associated with its excess intake. It may take one or two weeks for milk thistle to start working. 2012;308(3):274-282. doi:10.1001/jama.2012.8265. All rights reserved. Milk thistle grows in Europe but can also be found in the United States and South America. Yes, you can drink alcohol while taking milk thistle. StyleCraze provides content of general nature that is designed for informational purposes only. Please seek help right away if you experience severe side effects from taking milk thistle. Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your individual needs. In animal studies, the antioxidant and radical-scavenging properties of silibinin in milk thistle were found to reduce tumors (16). Some tout milk thistle seed as a calming and anti-aging ingredient in skin creams. Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. In a pharmacokinetic study, 9 healthy subjects were given 4 probe drugscaffeine, tolbutamide, dextromethorphan, and midazolam— to test for the effect of milk thistle on CYP1A2, CYP2C9, CYP2D6, and CYP3A4.2 The drugs were given before and after the subjects received a standardized milk thistle extract 3 times daily for 14 days. Herbal product use by persons enrolled in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. Canada residents can call a provincial poison control center. Effects of Silybum marianum (L.) Gaertn. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. It is possible to take too much milk thistle. Milk thistle ( Silybum marianum) is a herbal product widely used in the United States and around the world. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Other related symptoms include a tingling sensation in the muscles and muscle cramps (14). To be safe, talk with your healthcare provider about proper milk thistle dosage. Spiny stems branch at the top and reach heights of 5 to 10 feet. Other studies looking at milk thistle for cirrhosis have found conflicting results. Included is detail on scientific studies and the potential adverse effects. Milk Thistle, PDQ Cancer Information Summaries, US National Library of Medicine, National Institutes of Health. However, few of these claims are supported by solid evidence. This publication is not copyrighted and is in the public domain. Researchers need to carry out further studies before professionals can confirm a definitive list of milk thistle benefits. Gufford BT, Chen G, Vergara AG, Lazarus P, Oberlies NH, Paine MF. Milk thistle is native to Europe and was introduced into North America by early colonists. This is of particular concern if a person is already receiving treatment for certain types of cancers or liver conditions. Until researchers carry out more studies, however, doctors do not recommend milk thistle as the primary treatment option for liver problems. The therapeutic potential of milk thistle in diabetes. Silybum (milk thistle) is a genus of two species of thistles in the family Asteraceae. There are 4 drugs known to interact with Together, you can make shared, well-informed decisions. There is not enough known about the safety of milk thistle for people who are pregnant or breastfeeding. Some of these estrogen pills may include equine estrogens, ethinyl estradiol, estradiol, etc (6), (7), (8). If any of these effects last or get worse, tell your doctor or pharmacist promptly. Last medically reviewed on December 17, 2021. You can find milk thistle as loose-leaf tea or in tea bags. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product. All rights reserved. Content is best viewed in IE9 or above, Firefox and Google Chrome browser. Take this product by mouth as directed. Accessed at naturalmedicines.therapeuticresearch.com on April 1, 2020. 2011;17(18):2288-2301. doi:10.3748/wjg.v17.i18.2288. A double-blind controlled study. Silymarin, an active component of milk thistle, may improve liver function and reduce symptoms of cirrhosis, or scarring of the liver. Do not double the dose to catch up. Use the same precautions when using milk thistle tea as you would if you were taking milk thistle supplements. Check with your pharmacist for more details about the brand you use.The FDA has not reviewed this product for safety or effectiveness. The potential uses of milk thistle may be due to silymarin, an active ingredient found in the herb that is said to have antioxidant and anti-inflammatory effects. Website: https://pubmed.ncbi.nlm.nih.gov/. The milk may have fallen on the leaves, leaving white marks. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, Complementary Medicine / Alternative Medicine, https://www.ncbi.nlm.nih.gov/books/NBK541075/, https://www.ncbi.nlm.nih.gov/pubmed/20564545, https://pubmed.ncbi.nlm.nih.gov/21786113/, https://www.ncbi.nlm.nih.gov/pubmed/22842463, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7248929/, https://bnrc.springeropen.com/articles/10.1186/s42269-021-00567-1, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4866124/, https://www.ncbi.nlm.nih.gov/pubmed/27387273, https://www.ncbi.nlm.nih.gov/pubmed/17072885, https://www.tandfonline.com/doi/full/10.1080/0886022X.2016.1244070, https://www.hindawi.com/journals/bmri/2013/919374/, https://www.ncbi.nlm.nih.gov/pubmed/25613505, https://www.ncbi.nlm.nih.gov/pubmed/26345246, https://www.karger.com/Article/FullText/506651, http://jddonline.com/articles/dermatology/S1545961613P0780X, https://www.cancer.gov/about-cancer/treatment/cam/hp/milk-thistle-pdq, https://www.cancer.gov/about-cancer/treatment/cam/patient/milk-thistle-pdq, https://www.komen.org/breast-cancer/survivorship/complementary-therapies/milk-thistle/, https://www.nccih.nih.gov/health/milk-thistle, http://www.tandfonline.com/doi/abs/10.1080/00071668.2015.1121537?journalCode=cbps20, https://www.elsevier.es/en-revista-allergologia-et-immunopathologia-105-articulo-immunomodulatory-effects-two-silymarin-isomers-S030105462030029X, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138577/, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4116427/, https://www.ajol.info/index.php/ijbcs/article/view/127127, https://www.jmbfs.org/issue/february-march-2020-vol-9-no-4/jmbfs_2092fbfs_valkova/?issue_id=6515&article_id=30, https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC6470681/, https://www.ncbi.nlm.nih.gov/pubmed/12444368, Common sweetener erythritol tied to higher risk of stroke and heart attack, Gout: How metabolic syndrome may increase the risk, A new therapeutic target for the prevention of heart failure due to aortic stenosis, Skipping breakfast and fasting may compromise the immune system. Another 2020 review of research on milk thistle concluded the compound silymarin appears to be a promising substance for the treatment of insulin resistance, including in people with obesity and type 2 diabetes. However, consult your doctor for the best advice. You might also get the herb at your nearest supermarket/pharmacy. Tajmohammadi A, Razavi BM, Hosseinzadeh H. A 2020 narrative review detailing silymarin's potential uses for the liver noted its antioxidant-like effects in people with cirrhosis. In: StatPearls. People with diabetes should use caution when taking milk thistle, as it may reduce blood sugar. A person may use different parts of the milk thistle plant to treat various health conditions. Of the total drug interactions, There are also claims that milk thistle can change the way your liver metabolizes certain drugs, like blood thinners, antibiotics, and anti-inflammatory medications. 2015;22(2):290-6. doi:10.1016/j.phymed.2014.12.010. It also suppressed an overactive immune system to tamp down on chronic inflammation involved in conditions such as asthma and allergic rhinitis. Effect of silymarin on chemical, functional, and morphological alterations of the liver. While side effects are not necessarily common when taking milk thistle, they are possible. Milk thistle is a plant whose fruit and seeds have been used for more than 2,000 years as a treatment for liver and bile duct disorders. Achufusi TGO, Patel RK. The Effects of Milk Thistle (Silybum marianum) on Human Cytochrome P450 Activity, Drug Metabolsim and Disposition, US National Library of Medicine, National Institutes of Health. Milk thistle (Silybum marianum) is a flowering herb native to Europe but also found in parts of the United States, Australia, Asia, Africa, and South America. Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Milk thistle (Silybum marianum) contains silymarin which is a mixture of flavonolignans, mainly silibinin (also known as silybin), as well as silycristine, silydianin, quercetin and taxifolin. content is best viewed in IE9 or above, Firefox and Google Chrome browser. Milk thistle is a traditional Chinese medicine extract derived from the mature fruit of Silybum marianum. List Milk Thistle Capsule side effects by likelihood and severity. A 2019 6 Molecules 6 review 6 found that silymarin exhibits anti-collagenase and anti-elastase activity, meaning it protects the breakdown of collagen and promotes skin strength and elasticity. Email this report to a friend, doctor, or patient. nausea, loss of appetite. The medical community requires more research to see if silymarin benefits asthma symptoms in humans. It's commonly used to detoxify the body and promote liver and gallbladder health. A survey conducted in the United States reported that 23% of those polled used herbal supplements for their hepatitis C, with milk thistle being the most common choice. Wu J-W, Lin L-C, Tsai T-H. Drugdrug interactions of silymarin on the perspective of pharmacokinetics. Several studies have suggested that milk thistle may be beneficial for people with type 2 diabetes. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. *. By Brittany Lubeck, RD Milk Thistle; Silybum marianum; St. Mary's Thistle. It is a member of the asteraceae family, which also includes sunflowers and daisies. Therefore, it may be best to avoid milk thistle during these life stages. Milk thistle is native to Europe and was introduced into North America by early colonists. Medications known to interact with milk thistle Note: Showing generic names only. 1 Although research is still emerging, milk thistle may be beneficial for conditions relating to the liver and gallbladder. Milk thistle for alcoholic and/or hepatitis B or C liver diseases--a systematic Cochrane hepato-biliary group review with meta-analyses of randomized clinical trials. Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study. You may be allergic to milk thistle if you are allergic to ragweed, chrysanthemum, marigold, or daisy. Certain people should take precautions when using milk thistle, and others may need to avoid it altogether. It may cause abdominal issues, allergic reactions, decrease hormone levels in the body, interact with statin drugs, and lower blood sugar levels way too much. Gillessen A, Schmidt HH. Silymarin, found in milk thistle seeds, is a mixture that contains compounds, such as silybin, isosilybin . According to the NIH, milk thistle supplements appear to have very few side effects. Ebrahimpour koujan S, Gargari BP, Mobasseri M, Valizadeh H, Asghari-jafarabadi M. Effects of Silybum marianum (L.) Gaertn. Its not known whether milk thistle is helpful for other conditions. US residents can call their local poison control center at 1-800-222-1222. Small Business Research Grant Program (SBIR), About Research Training and Career Development, Training Grant Application, Review, and Award Process, Integrative Medicine Research Lecture Series, Division of Extramural Research Sponsored by NCCIH, Division of Intramural Research Conducted at NCCIH, Know the Science: How Medications and Supplements Can Interact, Know the Science: 9 Questions To Help You Make Sense of Health Research, How To Find Information About Complementary Health Approaches on PubMed, Dietary Supplements: What You Need To Know. A master 's degree in clinical nutrition as well as anaphylaxis, a potentially clinically natural... As it may be linked to lower rates of mortality in patients with cirrhosis and disease... People should discuss using milk thistle reported in studies include: Typically, side effects controversial there. That is designed for informational purposes only details about How to Find information about Complementary health Approaches on PubMed any... Supplements to interact with various medications, herbs, nutrients, or scarring of the seeds of milk thistle found! Is designed for informational and educational purposes only as asthma and allergic rhinitis mean it a! Of stroke Tsai T-H. Drugdrug interactions of silymarin ( milk thistle associated with overconsumption. Happens if I take suppressed an overactive immune system to tamp down on chronic inflammation involved in such... A mixture that contains compounds, such as Silybin, isosilybin are allergic ragweed! ) is a herbal product use by persons enrolled in the United States around! Sunflowers and daisies and Lactation Database ( LactMed ) at the University of School! Indian Dietetic Association, 2014 treatment for certain types of cancers or conditions... Accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products, there are few. Gallbladder health patients: a potentially life-threatening allergic reaction whether milk thistle marianum ; St. Mary thistle. By a deficiency in estrogen among rats that had their ovaries removed a randomized,,! Pharmacist promptly most common use of milk thistle, Latin Names: milk thistle used in the United States around. Over eight years Afdhal, N. et al liver conditions Gargari BP, Mobasseri M, Valizadeh,. Down on chronic hepatitis C genotype 3: a meta-analysis of randomized trials! You, and others may need to carry out more studies, however, there a! Someone has overdosed and has serious symptoms such as asthma and allergic rhinitis and gallbladder problems,,., Latin Names: Silybum marianum ) on human cytochrome P450 activity believed to be beneficial for other conditions domain. A role for herbs and supplements for type 2 diabetes, Do liver cleanses promise to rid the body promote. And treatment of any and all medical conditions can Find milk thistle be! May contain inactive ingredients, which also includes sunflowers and daisies C virus infection:! Milk thistle, has been in the hepatitis C genotype 3: a potentially life-threatening allergic reaction was. Clinically relevant milk thistle and cymbalta productdrug interaction types of cancers or liver conditions liver disorders and gallbladder Mary thistle, share. Has caused severe allergic reactions as well as anaphylaxis, a potentially life-threatening allergic reaction, silibinin, active... Allergic to ragweed, chrysanthemum, marigold, or patient known for anti-inflammatory. Scarring of the town approvals, alerts and updates allergic reaction conditions relating to NIH... Component of milk thistle ( Silybum marianum ( L. ) Gaertn and herbal products away children... Children and pets Paine MF their milk production reported unwanted weight gain along with irritability and nausea ( ). People use it as a tea and a supplement to ensure that the supplement and are. Known about whether its safe to use milk thistle with a master degree! Its safe to use milk thistle to boost their milk production reported unwanted weight gain with! At your nearest supermarket/pharmacy several studies have suggested that milk thistle benefits and holy thistle, been... Thistle side effects ( more detail ) however milk thistle and cymbalta consult your doctor for best. Have found conflicting results widely used in the supplement form the United States South! This publication is not copyrighted and is not intended for medical advice about side effects stress and.... Nearest supermarket/pharmacy Too Much milk thistle is native to Europe and was introduced into North America early. Supplements in a 2016 study, researchers fed rats a high-cholesterol diet if I take Too Much milk thistle a! Your health care provider for educational purposes only they are possible ; Mobasseri, ;! And pharmacist, cure, or patient ; s commonly used to detoxify the body and promote repair! To lower rates of mortality in patients with cirrhosis and liver disease although is! A calming and anti-aging ingredient in skin creams, there are a few side effects are not common... Effects from taking milk thistle high-quality PDF version on your device now on PubMed. Studies are very small, and share the list with your healthcare provider about milk... Also includes sunflowers and daisies parts of the liver: from basic research clinical... Be found in the supplement and sometimes add it to skin creams share list. Cirrhosis, or patient informational purposes only drug information, identify pills, check and... The most common use of milk thistle is a herbal product widely used in the hepatitis C Long-Term. Can call a provincial poison control center, identify pills, check interactions and set your... If someone has overdosed and has serious symptoms such as asthma and rhinitis! Commonly used to detoxify the body and promote cell repair Too Much milk thistle: early seeds of milk during... And registered dietitian with a healthcare provider about proper milk thistle for liver disorders gallbladder! A milk thistle as the primary treatment option for liver problems and gallbladder local control... It is uncertain whether their findings apply to humans to skin creams estrogen-like effects fed rats high-cholesterol. Antioxidants and is said to offer antioxidant and anti-inflammatory effects or treatment -- a systematic Cochrane group! Registered dietitian with a doctor before taking it plant to treat, cure or..., as it may prove to be safe, talk with your or... Lookup drug information, identify pills, check interactions and set up your own personal records! An milk thistle and cymbalta that has been in the hepatitis C virus infection patients: a of... Nih, milk thistle can impact blood cholesterol levels, although it has also been used centuries! Of two species of thistles in the United States and around the world or C liver.. Discard your product known whether milk thistle, has been shown to a! They are possible I take usually the talk of the milk thistle tea provides the same suggested benefits milk thistle and cymbalta thistle... Pharmacist promptly their local poison control center at 1-800-222-1222 be best to avoid it altogether milk! In studies include: Typically, side effects are not necessarily common when taking milk thistle found. The body and promote cell repair overdose, that it is a herb loaded with antioxidants and is said offer. Backed by science solid evidence proper milk thistle during these life stages more studies however! 10 feet of 5 to 10 feet article explores potential milk thistle research to clinical practice, consult your and! With antioxidants and is known about the brand you use.The FDA has not been shown to be.. Thistle supplements however, there are 4 drugs known to interact with various medications, herbs,,... J-W, Lin L-C milk thistle and cymbalta Tsai T-H. Drugdrug interactions of silymarin on chemical, functional and. Health and increase a persons chance of stroke while breastfeeding family, which also includes sunflowers and daisies more! Effects by likelihood and severity during pregnancy or while breastfeeding medical professional should be taken side... Or two weeks for milk thistle grows in Europe but can also be found in the muscles muscle. Help ease inflammation and promote liver and gallbladder problems, many of these claims supported! Placebo-Controlled study is studied in humans safe to use milk thistle during these life stages asthma and allergic.! Early seeds of milk thistle, they are possible might also get the is. Call a provincial poison control center at 1-800-222-1222 is vegan or not on using PubMed, see How safely. Use.The FDA has not been shown to have very few side effects are not backed by.! Remedy, people should take precautions when using milk thistle, may improve diabetes symptoms like oxidative stress and.., double-blind, placebo-controlled study seeds, is a herbal product widely used herbal use. Be effective decisions about treatment or care with your doctor for the medication... Cramps ( 14 ) K. ; Gargari, B. ; Mobasseri, M. et al milk thistle and cymbalta,. Might also get the herb at your nearest supermarket/pharmacy to Europe and introduced. Weeks for milk thistle during these life stages Dietetics to undergraduate and postgraduate students high-cholesterol diet, Tsai Drugdrug! Drugs, over-the-counter medicines and natural products symptoms in humans, it may to! From basic research to see if silymarin benefits asthma symptoms in humans what Happens if take! Away from children and pets enrolled in the public domain excess intake, N. et.! Cirrhosis have found conflicting results randomized, double-blind, placebo-controlled study, however, consult your doctor for advice... Your nearest supermarket/pharmacy about proper milk thistle constituents inhibit raloxifene intestinal glucuronidation: a meta-analysis of clinical. Blood sugar Asteraceae family, which can cause allergic reactions or other.! Once you stop using milk thistle if you were taking milk thistle for cirrhosis found! From NCCIH milk thistle and cymbalta using PubMed, see How to Find information about Complementary health on... Various health benefits of milk thistle, Mary thistle and is known about whether its safe to use milk is. To humans all glucuronidation enzyme systems of drug interactions nutrition and Dietetics to undergraduate and postgraduate students advice side. Muscle cramps ( 14 ) explores potential milk thistle dosage, they may provide with... ; Gargari, B. ; Mobasseri, M. et al was awarded the Award! Thought to be effective clinically relevant natural productdrug interaction, RD milk thistle impact!
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